Chemistry of Heterocyclic Compounds p. 342 - 354 (2011)
Update date:2022-08-04
Topics:
Potikha
Gutsul
Plaskon
Kovtunenko
Tolmachev
The reaction of 3-NHR-isoquinolin-1(2H)-ones (R∈=∈Ar) with aromatic aldehydes in the presence of Me3SiCl or in acetic acid leads to the formation of derivatives of dibenzo[b,f][1, 8]naphthyridin-5(6H)- one and benzo[f]isoquino[3,4-b][1, 8]naphthyridine-5,9(6H,7H)-dione. The reaction for R∈=∈Het in the presence of Me3SiCl gives derivatives of 5H-pyrido[1′,2′:1,2]pyrimido[4,5-c]isoquinolin-5-one, benzo[f]isoquinoline[3,4-b][1,8]naphthyridine-5,9[6H,7H]-dione, and derivatives of new heterocyclic systems, 5H-pyrazino[1′,2′:1,2]pyrimido[4,5-c] isoquinolin-5-one, 5H-[1,3]thiazolo[3′,2′:1,2]pyrimido- [4,5-c]isoquinolin-5-one, 5-H-benzo[f]pyrazolo[3,4-b][1,8]naphthyridin-5-one, and isoquino[3,4-b]- [1,5]naphthyridin-5(6H)-one. The effect of the structure of substituent R and nature of the substituent in the benzaldehydes on the structure of the reaction products was studied.
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