The Synthesis and Potassium Channel Blocking Activity of Some (4-Methanesulfonamidophenoxy)propanolamines as Potential Class III Antiarrhythmic Agents

DOI: 10.1021/jm00109a007

Source and publish data:

Journal of Medicinal Chemistry p. 1570 - 1577 (1991)

Update date:2022-08-03

Topics:

Authors:

Connors, Sean P.

Dennis, Paul D.

Gill, Edward W.

Terrar, Derek A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00109a007

The synthesis of 22 (4-methanesulfonamidophenoxy)propanolamines and their testing on isolated guinea pig cardiac myocytes, on isolated preparations from guinea pig atria, and on rat blood pressure are described.Secondary amines in the series (11a-f) showe

Full text of DOI:10.1021/jm00109a007

Products guided by the article

Product name:3-Isopropyl-5-(4-nitro-phenoxymethyl)-2-phenyl-oxazolidine

Cas No:133229-42-2

R&D Labs maybe for 133229-42-2

Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Xinjiang Zhongtai Chemical Co., Ltd.

Contact:+86-991-8788172

Address:NO.78 XISHAN RD.URUMQI，CHINA
Xinjiang Zhongtai Chemical Co., Ltd.

Contact:+86-991-8788172

Address:NO.78 XISHAN RD.URUMQI，CHINA
Changyi Xinxing Technology Development Co., Ltd.

Contact:0086-510-86651065(Time Zone:8),86651656

Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.

Contact:15967177856

Address:Genglou Industrial Development Area

Relevant to this article

Synthesis, antibacterial, and analgesic activity of novel 4-hydroxy-3-(phenylthio)-2H-chromen-2-ones and 4-Hydroxy-3-[imidazol/tetrazolo- 2-yl)thio]-2H-chromen-2-ones

Doi:10.1080/10426507.2010.530630
(2011)
Isocyanide-based three-component synthesis of pyrano-pyrido-quinoxalines

Doi:10.1002/hlca.201100019
(2011)
Fused indolines by palladium-catalyzed asymmetric C-C coupling involving an unactivated methylene group

Doi:10.1002/anie.201102639
(2011)
Novel stereoselective glycosidation by the combined use of trityl halide and Lewis acid

Doi:10.1248/cpb.38.3280
(1990)
Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity

Doi:10.1021/ml200176m
(2011)
Synthesis and antiradiation activity of some sulfur containing thiophene derivatives

Doi:10.1080/10426509808545453
(1998)

Article Doi