The Synthesis and Potassium Channel Blocking Activity of Some (4-Methanesulfonamidophenoxy)propanolamines as Potential Class III Antiarrhythmic Agents

DOI: 10.1021/jm00109a007

Source and publish data:

Journal of Medicinal Chemistry p. 1570 - 1577 (1991)

Update date:2022-08-03

Topics:

Authors:

Connors, Sean P.

Dennis, Paul D.

Gill, Edward W.

Terrar, Derek A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00109a007

The synthesis of 22 (4-methanesulfonamidophenoxy)propanolamines and their testing on isolated guinea pig cardiac myocytes, on isolated preparations from guinea pig atria, and on rat blood pressure are described.Secondary amines in the series (11a-f) showe

Full text of DOI:10.1021/jm00109a007

Products guided by the article

Product name:3-Isopropyl-5-(4-nitro-phenoxymethyl)-2-phenyl-oxazolidine

Cas No:133229-42-2

R&D Labs maybe for 133229-42-2

Hebei Tianxiang Biological & Pharmaceutical Co., Ltd

Contact:86-0312-6615158

Address:No 42 fazhan street qingyuan county
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Xi'an Herbland Tech Inc.

Contact:+86-29-88710656

Address:South Tai bai Road, High Tech Development Zone, Xi'an China
Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
Nantong LiKai Chemical Co.,Ltd

Contact:+86-513-89068669

Address:Jincheng Science Park

Relevant to this article

Synthesis, antibacterial, and analgesic activity of novel 4-hydroxy-3-(phenylthio)-2H-chromen-2-ones and 4-Hydroxy-3-[imidazol/tetrazolo- 2-yl)thio]-2H-chromen-2-ones

Doi:10.1080/10426507.2010.530630
(2011)
Isocyanide-based three-component synthesis of pyrano-pyrido-quinoxalines

Doi:10.1002/hlca.201100019
(2011)
Fused indolines by palladium-catalyzed asymmetric C-C coupling involving an unactivated methylene group

Doi:10.1002/anie.201102639
(2011)
Novel stereoselective glycosidation by the combined use of trityl halide and Lewis acid

Doi:10.1248/cpb.38.3280
(1990)
Systematic chemical mutagenesis identifies a potent novel apratoxin A/E hybrid with improved in vivo antitumor activity

Doi:10.1021/ml200176m
(2011)
Synthesis and antiradiation activity of some sulfur containing thiophene derivatives

Doi:10.1080/10426509808545453
(1998)

Article Doi