SYNTHESIS OF (-)-(4R,5R)- AND (+)-(4S,5S)-1-ALKYL-4-(4'-NITROPHENYL)-1-AZONIUM-3,7-DIOXABICYCLOOCTANE HALIDES

Article abstract of DOI:10.1007/BF00472192

A preparative method has been proposed for the synthesis of bicyclic quaternary ammonium salts via sequential treatment of (-)-(1R,2R)- and (+)-(1S,2S)-1-(4'-nitrophenyl)-2-amino-1,3-propanediol with paraform followed by an alkyl halide.