Angewandte Chemie - International Edition p. 7803 - 7806 (2011)
Update date:2022-08-04
Topics:
Kawai, Hiroyuki
Tachi, Kentaro
Tokunaga, Etsuko
Shiro, Motoo
Shibata, Norio
It all adds up: The activation of aromatic isoxazoles with a nitro group at the 4-position has enabled the first regio- and diastereoselective trifluoromethylation at the 5-position of isoxazoles by nucleophilic addition using Me3SiCF3 (see scheme; DMF=N,N′- dimethylformamide). The process was demonstrated with a broad range of 3,5-aromatic, heteroaromatic and aliphatic substrates.
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Doi:10.1016/S0040-4020(01)87078-2
(1991)Doi:10.1016/j.carres.2011.05.031
(2011)Doi:10.1016/0008-6215(96)00015-8
(1996)Doi:10.1002/chem.201805055
(2018)Doi:10.1021/ol202076c
(2011)Doi:10.1002/ejoc.201100579
(2011)
