4
Tetrahedron
b Total isolated yields of 2 and 3 based on 1.
4.
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c Determined by H-NMR of the crude mixture.
5.
Conclusion
In conclusion, we have demonstrated the selective cyanation
of 4-substitute-pyridazine via regionselective Reissert–type
reaction to get 5-substituted-3-pyridazinecarbonitrile. The
regioselectivity was influenced by the steric effect as well as the
electronic characteristics of the substituent, high steric hindrance
or electron-donating group on the substrates benefit the
generation of desired product. The functionalized 5-substituted
pyridazine-3-carbonitrile are useful intermediates in bioactive
molecules.
6.
7.
Acknowledgments
We are grateful to Technology Research and Development
Funds of Zhengzhou (141PRCYY516) for financial support.
8.
9.
References and notes
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