The asymmetric Friedel-Crafts reaction of indoles with fluoroalkylated nitroalkenes catalyzed by chiral phosphoric acid

DOI: 10.1002/ejoc.201100683

Source and publish data:

European Journal of Organic Chemistry p. 4536 - 4539 (2011)

Update date:2022-08-03

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Authors:

Lin, Jin-Hong

Xiao, Ji-Chang

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Article abstract of DOI:10.1002/ejoc.201100683

The enantioselective Friedel-Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO₂ group.

Full text of DOI:10.1002/ejoc.201100683

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