
Journal of Fluorine Chemistry p. 411 - 426 (1990)
Update date:2022-08-02
Topics:
Clark, James H.
Denness, James E.
McClinton, Martin A.
Wynd, Andrew J.
The in situ generation of CuCF3 from the reaction of copper, dibromodifluoromethane and either N,N-dimethylformamide or N,N-dimethylacetamide (Burton's reagent) has been used for the direct substitution of chlorine by CF3 in a number of aromatic substrates.Particular attention has been paid to the effects of ring substituents on the efficiency of reaction.
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