FURTHER EVIDENCE FOR THE INVOLVEMENT OF A MONOCYCLIC β-LACTAM IN THE ENZYMATIC CONVERSION OF δ-L-α-AMINOADIPOYL-L-CYSTEINYL-D-VALINE INTO ISOPENICILLIN N

DOI: 10.1016/S0040-4020(01)90503-4

Source and publish data:

Tetrahedron p. 457 - 480 (1991)

Update date:2022-08-02

Topics:

Authors:

Baldwin, J. E.

Bradley, M.

Adlington, R. M.

Norris, W. J.

Turner, N. J.

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Article abstract of DOI:10.1016/S0040-4020(01)90503-4

Incubation of δ-L-α-aminoadipoyl-L-<3-13C>cysteinyl-D-<3-2H>valine with Isopenicillin N Synthase (IPNS) resulted of a 'shunt metabolite', which we believe is formed from the collapse of an enzyme bound monocyclic β-lactam intermediate.Chemical studies int

Full text of DOI:10.1016/S0040-4020(01)90503-4

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