Journal of the Chemical Society. Chemical communications p. 817 - 819 (1992)
Update date:2022-08-04
Topics:
Baker, Raymond
Showell, Graham A.
Street, Leslie J.
Saunders, John
Hoogsteen, Karst
et al.
The cyclopropyloxadiazole derivative described in the title has been shown to be a functionally selective M1 partial agonist with antagonist properties in M2 and M3 muscarinic receptor assays; conformational studies indicate free rotation around the oxadiazole-azanorbornane bond, whilst X-ray studies reveal that the cyclopropyl group is in conjugation with the oxadiazole C=N bond.
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