Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1

DOI: 10.1016/j.ejmech.2011.05.018

Source and publish data:

European Journal of Medicinal Chemistry p. 3551 - 3563 (2011)

Update date:2022-08-05

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Authors:

Lu, Xiaoyun

Wan, Baojie

Franzblau, Scott G.

You, Qidong

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Article abstract of DOI:10.1016/j.ejmech.2011.05.018

A series of 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl) thiophene-3-carboxylic acid derivatives were synthesized and evaluated for anti-tubercular activity. Among these compounds, 10d, 15, 12h and 12k inhibited Mycobacterium tuberculosis (Mtb

Full text of DOI:10.1016/j.ejmech.2011.05.018

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