Tetrahedron Letters p. 3051 - 3054 (1993)
Update date:2022-08-05
Topics:
Deeter, Jack B.
Hall, David A.
Jordan, Christopher L.
Justice, Richard M.
Kinnick, Michael D.
et al.
A new method for the synthesis of chiral azetidinones bearing a carbon-carbon bond at the 4-position is described.The preparation involves a stereoselective alkylation-reduction of a silylated 4-phenylsulfonyl azetidinone.The utility of this method was demonstrated by a formal total synthesis of loracarbef.
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Doi:10.1002/cmdc.201800707
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