Highly Felkin-Anh Selective Hiyama Additions of Chiral Allylic Bromides to Aldehydes. Application to the First Synthesis of Nephromopsinic Acid and Its Enantiomer

DOI: 10.1021/ja00011a025

Source and publish data:

Journal of the American Chemical Society p. 4218 - 4229 (1991)

Update date:2022-08-03

Topics:

Authors:

Mulzer, Johann

Kattner, Lars

Strecker, Achim R.

Schr?der, Christian

Buschmann, Jürgen

Lehmann, Christian

Luger, Peter

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Article abstract of DOI:10.1021/ja00011a025

The chromium(II)-mediated addition ("Hiyama reaction") of the chiral allylic bromides 13, 15, 19, 22, 24, and 27 to achiral and chiral aldehydes proceeds with high Felkin-Anh selectivity with respect to the stereocenter at Cγ in the bromide (Table II). By

Full text of DOI:10.1021/ja00011a025

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