Alkylation of nucleosides by dehydromonocrotaline, the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline

DOI: 10.1016/S0040-4039(00)92122-1

Source and publish data:

Tetrahedron Letters p. 927 - 930 (1991)

Update date:2022-09-26

Topics:

Authors:

Niwa Niwa

Ogawa Ogawa

Okamoto Okamoto

Yamada Yamada

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Article abstract of DOI:10.1016/S0040-4039(00)92122-1

Reactin of dehydromonocrotaline (3), the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline (2), with various nucleosides proceeded mostly at the C-9'' position of 3 to give several nitrogen atom-alkylated including N-7 alkylated 2'-deoxyguanosine 14.

Full text of DOI:10.1016/S0040-4039(00)92122-1

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