Alkylation of nucleosides by dehydromonocrotaline, the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline

Article abstract of DOI:10.1016/S0040-4039(00)92122-1

Reactin of dehydromonocrotaline (3), the putative toxic metabolite of the carcinogenic pyrrolizidine alkaloid monocrotaline (2), with various nucleosides proceeded mostly at the C-9'' position of 3 to give several nitrogen atom-alkylated including N-7 alkylated 2'-deoxyguanosine 14.