REGIOCONTROLLED CONVERSION OF α,α-UNSATURATED KETONES TO OLEFINS VIA ALLYLSILANES: SYNTHESIS OF dl-9(O)-METHANO-Δ6(9α)-PGI1

Article abstract of DOI:10.1016/S0040-4039(00)86022-0

A synthesis of dl-9(O)-methano-Δ^6(9α)-PGI₁ (1), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.