REGIOCONTROLLED CONVERSION OF α,α-UNSATURATED KETONES TO OLEFINS VIA ALLYLSILANES: SYNTHESIS OF dl-9(O)-METHANO-Δ6(9α)-PGI1

DOI: 10.1016/S0040-4039(00)86022-0

Source and publish data:

Tetrahedron Letters p. 3497 - 3500 (1983)

Update date:2022-08-03

Topics:

Authors:

Shibasaki, Masakatsu

Fukasawa, Hidemi

Ikegami, Shiro

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Article abstract of DOI:10.1016/S0040-4039(00)86022-0

A synthesis of dl-9(O)-methano-Δ^6(9α)-PGI₁ (1), a more potent prostacyclin analog than carbacyclin, has been accomplished utilizing regiocontrolled transformation of the enone to the olefin via the allylsilane as a key step.

Full text of DOI:10.1016/S0040-4039(00)86022-0

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