Synthesis and conjugate additions to (E)-γ-alkoxy-α-substituted-α,β-unsaturated sulfones

Article abstract of DOI:10.1016/S0040-4039(00)79674-2

(E)-γ-hydroxy-α,β-unsaturated sulfones have been readily functionalized at α-position via protection of hydroxyl group, metalation with n-BuLi and subsequent reaction with electrophiles. The conjugate addition of organolithiums to (E)-γ-methoxymethoxy-α-trimethylsilyl-α,β-unsaturated phenyl sulfones in Et₂O is highly syn-stereoselective