Palladium-catalyzed diastereoselective cyclization of the allylic precursors. A concise synthetic route to 3-azabicyclo[3.3.0]Octane and hydroisoindole skeletons

Article abstract of DOI:10.1080/00397910008087454

A useful variant of palladium-catalyzed 1,2-diastereoselective cyclization of the allylic precursors based on the steric nature of the anion stabilizing groups has been developed. The 1,1,2-trisubstituted cycloalkane products have also been efficiently transformed into the azabicyclic systems.

Full text of DOI:10.1080/00397910008087454

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Synthetic Communications: An
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Palladium-Catalyzed
Diastereoselective Cyclization
of the Allylic Precursors. A
Concise Synthetic Route to 3-
Azabicyclo[3.3.0]Octane and
Hydroisoindole Skeletons
Young-Ger Suh a , Young-Choon Lee a , Jung-Ae Ko a ,
Soon-Ai Kim a , Jee-Young Kim a , Jae-Kyung Jung a ,
Seung-Yong Seo a & Kee-Ho Lee a
a College of Pharmacy, Seoul National University ,
San 56–1, Shinrim-Dong, Kwanak-Gu, Seoul, 151–742,
Korea
Published online: 04 Dec 2007.
To cite this article: Young-Ger Suh , Young-Choon Lee , Jung-Ae Ko , Soon-Ai Kim ,
Jee-Young Kim , Jae-Kyung Jung , Seung-Yong Seo & Kee-Ho Lee (2000) Palladium-
Catalyzed Diastereoselective Cyclization of the Allylic Precursors. A Concise Synthetic
Route to 3-Azabicyclo[3.3.0]Octane and Hydroisoindole Skeletons, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 30:16, 3053-3060, DOI: 10.1080/00397910008087454
To link to this article: http://dx.doi.org/10.1080/00397910008087454
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