Tetrahedron p. 1887 - 1894 (1991)
Update date:2022-09-26
Topics:
Radunz, Hans-Eckart
Eiermann, Volker
Schneider, Guenther
Riethmueller, Angelika
γ-Lactones 6,8,10 and the ester 9, precursors to the hydroxyethylene dipeptide isostere unit, were synthesized stereoselectively in two or three steps from α-amino-ketones in good yield. Peptides containing these isosteres are potent inhibitors of certain aspartyl proteinases. Alkylation of the (3S,4S)substituted γ-lactone 6 afforded exclusively cis-alkylation, with regard to C-2 and C-4.
View MoreJi'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Buffett (China) Holding Co.,Ltd
Contact:4006570891
Address:
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Cerametek Materials（ShenZhen）Co., Ltd.
Contact:+86-755-2324.2554
Address:A3-#9, YongChuan Street, Suite 501
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD
website:http://www.xypharm.com/
Contact:+86-515-84383317
Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Doi:10.1016/j.tetlet.2011.09.029
(2011)Doi:10.1016/j.mencom.2011.09.004
(2011)Doi:10.1016/j.bioorg.2019.103439
(2020)Doi:10.1002/ejoc.201400042
(2014)Doi:10.1021/ja208867g
(2011)Doi:10.1021/jacs.7b06794
(2017)
