Synthesis and biological activities of optical isomers of 2-(4-chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-o ne 7-oxide

DOI: 10.1248/cpb.40.117

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 117 - 121 (1992)

Update date:2022-08-06

Topics:

Authors:

Nakao Nakao

Obata Obata

Yamaguchi

Marubayashi

Ikeda Ikeda

Morimoto

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Article abstract of DOI:10.1248/cpb.40.117

Two enantiomers of 2-(4-chlorophenyl)-5,6-dihydro-(1)benzothiepino[5,4-c]pyridazin-3(2H)-o ne 7-oxide ((±)-1: Y-23684) were synthesized in high yields by asymmetric oxidation of the synthetic precursor (2) using modified Sharples reagent. Among the oxidan

Full text of DOI:10.1248/cpb.40.117

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