Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides

DOI: 10.1021/jm00112a007

Source and publish data:

Journal of Medicinal Chemistry p. 2361 - 2366 (1991)

Update date:2022-08-04

Topics:

Authors:

Secrist, John A.

Tiwari, Kamal N.

Riordan, James M.

Montgomery, John A.

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Article abstract of DOI:10.1021/jm00112a007

2'-Deoxy-4'-thiocytidine (7β), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro.All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also act

Full text of DOI:10.1021/jm00112a007

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