A Short and Facile Synthetic Route to Hydroxylated Flavones. New Syntheses of Apigenin, Tricin, and Luteolin

DOI: 10.1021/jo00016a015

Source and publish data:

Journal of Organic Chemistry p. 4884 - 4887 (1991)

Update date:2022-08-02

Topics:

Authors:

Nagarathnam, Dhanapalan

Cushman, Mark

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Article abstract of DOI:10.1021/jo00016a015

Reaction of lithium polyanions generated from o-hydroxyacetophenones 3a-f with O-silyloxylated benzoates 2a-d gave 1-aryl-3-(2-hydroxyphenyl)-1,3-propanediones 4a-n, which on treatment with acetic acid containing 0.5percent H2SO4 at 95 - 100 deg C afforded hydroxylated flavones 5-18 in high yields (76 - 92percent).

Full text of DOI:10.1021/jo00016a015

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