Rapid and stereoselective construction of dienediynes related to the neocarzinostatin chromophore

Article abstract of DOI:10.1016/0040-4039(91)80355-A

Formylcyclopentanone was transformed into Z configuration dienediynes 15 in three steps. As the key step served Pd catalyzed stereoselective couplings of the isomerically pure bis(enoltriflate) 13 with two equiv. of alkyne.