Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor

DOI: 10.1021/acs.oprd.5b00131

Source and publish data:

Organic Process Research and Development p. 865 - 871 (2015)

Update date:2022-08-04

Topics:

Authors:

Curtis, Neil R.

Davies, Suzanne H.

Gray, Matthew

Leach, Stuart G.

McKie, Ross A.

Vernon, Lois E.

Walkington, Andrew J.

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Article abstract of DOI:10.1021/acs.oprd.5b00131

A large-scale process for the synthesis of SYK inhibitor 1 has been developed and used to deliver multi-kilogram yields of this active pharmaceutical ingredient. Integral to the scalable process is a combined chiral auxiliary and chiral catalyst mediated

Full text of DOI:10.1021/acs.oprd.5b00131

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