Discovery of novel cobactin-t based matrix metalloproteinase inhibitors via a ring closing metathesis strategy

DOI: 10.1016/j.bmcl.2011.08.068

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6485 - 6490 (2011)

Update date:2022-08-05

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Authors:

Wilson, Lawrence J.

Wang, Bingbing

Yang, Shyh-Ming

Scannevin, Robert H.

Burke, Sharon L.

Karnachi, Prabha

Rhodes, Kenneth J.

Murray, William V.

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Article abstract of DOI:10.1016/j.bmcl.2011.08.068

The discovery of potent N-hydroxyl caprolactam matrix metalloproteinase (MMP) inhibitors (6) based on the natural product Cobactin-T (2) is described. The synthetic method, which utilizes the ring closing metathesis reaction, is compatible to provide comp

Full text of DOI:10.1016/j.bmcl.2011.08.068

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