Bioconjugate Chemistry p. 1314 - 1323 (2016)
Update date:2022-08-04
Topics: Imaging Conjugates 68Ga Bivalent Polypegylated Styrylpyridine Aβ Plaques Cerebral Amyloid Angiopathy
Zha, Zhihao
Song, Jin
Choi, Seok Rye
Wu, Zehui
Ploessl, Karl
Smith, Megan
Kung, Hank
Aβ plaques deposited on blood vessels are associated with cerebral amyloid angiopathy (CAA). In an effort to selectively map these Aβ plaques, we are reporting a new series of 68Ga labeled styrylpyridine derivatives with high molecular weights. In vitro binding to Aβ plaques in post-mortem Alzheimer's disease (AD) brain tissue showed that these 68Ga labeled bivalent styrylpyridines displayed good affinities and specificity (Ki < 30 nM). In vitro autoradiography using post-mortem AD brain sections showed specific binding of these 68Ga complexes to Aβ plaques. Biodistribution studies in normal mice showed very low initial brain uptakes (<0.3% dose/g) indicating a low blood-brain barrier (BBB) penetration. The preliminary results suggest that 68Ga labeled bivalent styrylpyridines may be promising candidates as PET imaging radiotracers for detecting CAA.
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