Aluminium chloride mediated aminolysis of lactones: A general method for the preparation of ω-hydroxyalkylamides

DOI: 10.1055/s-1991-26451

Source and publish data:

Synthesis p. 306 - 308 (1991)

Update date:2022-08-03

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Lesimple

Bigg Bigg

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Article abstract of DOI:10.1055/s-1991-26451

Medium-ring lactones react cleanly with primary and secondary aliphatic or aromatic amines in the presence of aluminium chloride at room temperature to afford ω-hydroxyalkylamides in high yield.

Full text of DOI:10.1055/s-1991-26451

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