ASYMMETRIC ALKYLATIONS OF N-ACYL DIHYDROPYRIMIDINONES

Article abstract of DOI:10.1016/S0957-4166(00)80528-5

Enantiomerically pure dihydropyrimidin-4-one 1 has been employed as a chiral auxiliary for enantioselective alkylation reactions.Acylation of 1, followed by enolate formation, alkylation and acyl cleavage, affords α-alkylated carboxylic acids in high chemical yield and enantiomeric purity.