Tetrahedron Asymmetry p. 105 - 108 (1991)
Update date:2022-07-29
Topics:
Negrete, George R.
Konopelski, Joseph P.
Enantiomerically pure dihydropyrimidin-4-one 1 has been employed as a chiral auxiliary for enantioselective alkylation reactions.Acylation of 1, followed by enolate formation, alkylation and acyl cleavage, affords α-alkylated carboxylic acids in high chemical yield and enantiomeric purity.
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Doi:10.1002/anie.201104588
(2011)Doi:10.1016/j.saa.2012.05.087
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(2011)Doi:10.1021/bi201657k
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(2011)
