5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and related 4-amino compounds: Synthesis and pharmacological evaluation

DOI: 10.1002/jps.2600800412

Source and publish data:

Journal of Pharmaceutical Sciences p. 341 - 348 (1991)

Update date:2022-08-06

Topics:

Authors:

Dal Piaz

Ciciani Ciciani

Turco Turco

Giovannoni

Miceli Miceli

Pirisino

Perretti

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Article abstract of DOI:10.1002/jps.2600800412

Several 4-nitro- and 4-amino-5-acyl-6-aryl-3(2H)pyridazinones were prepared and their in vitro and ex vivo antiaggregatory properties were evaluated. 4-Nitro derivatives 3 generally showed good activity in vitro towards arachidonic acid (AA)-induced human

Full text of DOI:10.1002/jps.2600800412

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