Asymmetric syntheses of 3-substituted-cyclohexanone derivatives by stereoselective conjugate addition to chiral 2-substituted-2-cyclohexen-1-ones

Article abstract of DOI:10.1021/ja00013a031

Chiral 2-substituted-2-cyclohexen-1-one 2a is prepared from 1a by Birch reduction followed by acid-catalyzed hydrolysis-olefin migration. Conjugate additions of organometallic reagents to 2a occur with good to excellent diastereoselectivities (Table I). E