3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, a new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4- (trifluoromethyl)phenyl]-2-butenamide

DOI: 10.1021/jm00081a011

Source and publish data:

Journal of Medicinal Chemistry p. 507 - 510 (1992)

Update date:2022-08-05

Topics:

Authors:

Patterson

Cheung Cheung

Ernest Ernest

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Article abstract of DOI:10.1021/jm00081a011

The title compound 3-carboxyisoxazole 3 was synthesized by cycloaddition of carbethoxyformonitrile oxide to N-[4-(trifluoromethyl)phenyl]-3- pyrrolidino-2-butenamide (6) with spontaneous elimination of pyrrolidine followed by hydrolysis of the ethyl ester

Full text of DOI:10.1021/jm00081a011

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