3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, a new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4- (trifluoromethyl)phenyl]-2-butenamide

DOI: 10.1021/jm00081a011

Source and publish data:

Journal of Medicinal Chemistry p. 507 - 510 (1992)

Update date:2022-08-05

Topics:

Authors:

Patterson

Cheung Cheung

Ernest Ernest

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00081a011

The title compound 3-carboxyisoxazole 3 was synthesized by cycloaddition of carbethoxyformonitrile oxide to N-[4-(trifluoromethyl)phenyl]-3- pyrrolidino-2-butenamide (6) with spontaneous elimination of pyrrolidine followed by hydrolysis of the ethyl ester

Full text of DOI:10.1021/jm00081a011

Products guided by the article

Product name:3-Isoxazolecarboxylic acid, 5-methyl-4-[[[4-(trifluoromethyl)phenyl]amino]carbonyl]-, ethyl ester

Cas No:134889-01-3

R&D Labs maybe for 134889-01-3

Chengdu Cogon Bio-tech Co., Ltd.

Contact:86-28-85171192

Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
SOGA ENTERPRISES ASIA GROUP

Contact:+86-633-8332928

Address:No.1,Huanghai Yilu.Rizhao,Shandong
Shanghai Apeptide Co., Ltd.

website:http://www.apeptides.com/en/

Contact:+86-21-60871011

Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Weifang Ocean Trading Co., Ltd.

Contact:+86-536-2081155

Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China

Relevant to this article

Regiospecific synthesis of 1, 2-disubstituted (hetero)aryl fused imidazoles with tunable fluorescent emission

Doi:10.1021/ol202807d
(2011)
Synthesis of the novel pyrimido[1,6-a]pyrimidine and imidazo[1,2-c] pyrimidine derivatives based on heterocyclic ketene aminals

Doi:10.1016/j.tet.2011.10.035
(2012)
Palladium-Catalyzed [4 + 3] or [2 + 2 + 3] Annulation via C-H Activation and Subsequent Decarboxylation: Access to Heptagon-Embedded Polycyclic Aromatic Hydrocarbons

Doi:10.1021/acs.orglett.1c00520
(2021)
Palladium-Catalyzed Intermolecular Aerobic Annulation of o-Alkenylanilines and Alkynes for Quinoline Synthesis

Doi:10.1021/acs.orglett.6b01008
(2016)
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7

Doi:10.1016/j.ejmech.2011.12.005
(2012)
The first general synthesis of 2-C-(β-d-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes

Doi:10.1039/c8nj04035d
(2018)

Article Doi