Amide Bond Replacements: Incorporation of a 2,5,5-Trisubstituted Imidazoline into Dipeptides and into a CCK-4 Derivative.

Article abstract of DOI:10.1016/S0040-4039(00)79701-2

Synthetic methodology for the introduction of a 2,5,5-trisubstituted imidazoline ring as an amide replacement into dipeptide derivatives of Phe, Trp, Lys(N⁶-CBZ) and Nle is described.This replacement is also incorporated into the Trp-Nle bond o