Synthesis of 2-Substituted 8-Amino-3-oxoindolizidine-2-carboxylic Acid Derivatives as Peptide Conformation Mimetics

DOI: 10.1016/S0040-4020(01)90127-9

Source and publish data:

Tetrahedron p. 5191 - 5198 (1992)

Update date:2022-07-29

Topics:

Authors:

Gonzalez-Muniz, Rosario

Dominguez, Maria Jose

Garcia-Lopez, Maria Teresa

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Article abstract of DOI:10.1016/S0040-4020(01)90127-9

The synthesis of methyl 8-tert-butyloxycarbonylamino-3-oxoindolizidine-2-carboxylate and its alkyl derivatives bearing Phe, Trp and Asp side chains at C₂ position are described.These bridged bicyclic lactams, obtained with high and moderate ste

Full text of DOI:10.1016/S0040-4020(01)90127-9

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