Monatshefte fur Chemie p. 283 - 290 (1991)
Update date:2022-09-26
Topics:
Noe, Christian R.
Knollmueller, Max
Goestl, Georg
Gaertner, Peter
The synthesis of both enantiomers of norephedrine and norisoephedrine is described to present a method for the preparation of enantiomerically pure branched 1,2-aminoalcohols.In a one pot reaction enantiomerically pure cyanohydrins bearing an acetal protective group are subjected to Grignard-reaction followed by addition of lithium aluminium hydride.After deprotection the target compounds are obtained.
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