Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

Article abstract of DOI:10.1016/j.ejmech.2009.11.024

We describe herein asymmetric synthesis of a novel anticancer β-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these β-lactams are also reported here.