Asymmetric synthesis of α-hydroxyethyl β-lactam derivatives: An approach to thienamycin

DOI: 10.1016/S0040-4039(00)78789-2

Source and publish data:

Tetrahedron Letters p. 2577 - 2580 (1991)

Update date:2022-09-26

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Authors:

Ma, Chun

Miller, Marvin J.

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Article abstract of DOI:10.1016/S0040-4039(00)78789-2

The asymmetric synthesis of a β-lactam ring with three contiguous chiral centers, including a hydroxyethyl side chain, was accomplished by the preparation and oxidative cyclization of the appropriate β,γ-unsaturated hydroxamate.

Full text of DOI:10.1016/S0040-4039(00)78789-2

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