Asymmetric synthesis of α-hydroxyethyl β-lactam derivatives: An approach to thienamycin

Article abstract of DOI:10.1016/S0040-4039(00)78789-2

The asymmetric synthesis of a β-lactam ring with three contiguous chiral centers, including a hydroxyethyl side chain, was accomplished by the preparation and oxidative cyclization of the appropriate β,γ-unsaturated hydroxamate.