A new synthesis of N-substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones

Article abstract of DOI:10.1080/00397919308011228

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate (LTA) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage (method B or C), or two stages (method A). The latter method was particularly developed to explain the mechanism of the reaction.