Journal of Organic Chemistry p. 4555 - 4563 (1993)
Update date:2022-08-05
Topics:
Solladie, Guy
Lohse, Olivier
A new enantioselective synthesis of (+)-brefeldin A is described.The five chiral centers are created by the following methodology: asymmetric Diels-Alder reaction to prepare the cyclopentanone 13, stereocontrolled reduction of the carbonyl in the ketone 14, stereocontrolled creation of the chiral centers C-4 and C-15 by a chiral sulfoxide group.
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