A CONVENIENT SYNTHESIS OF 5-ETHOXY-4-(TRIFLUOROMETHYL)-2-OXAZOLECARBOXYLIC ACID AND RELATED TRIFLUOROMETHYL SUBSTITUTED HETEROCYCLIC COMPOUNDS

DOI: 10.1016/S0022-1139(00)80131-1

Source and publish data:

Journal of Fluorine Chemistry p. 149 - 157 (1991)

Update date:2022-08-04

Topics: Synthesis Melting point NMR spectroscopy Catalyst Nucleophile Electrophile Solvent Chromatography Recrystallization Mass spectrometry (MS) Purification Reaction Mechanism Substitution Reaction Reaction Optimization Heterocyclic compound Reaction yield Oxazole Carboxylic acid (-COOH)

Authors:

Shi, Guoqiang

Xu, Yuanyao

Xu, Ming

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Article abstract of DOI:10.1016/S0022-1139(00)80131-1

5-Ethoxy-4-(trifluoromethyl)-2-oxazolecarboxylic acid 4 has been obtained from the corresponding ethyl ester prepared by rhodium-catalysed reaction of ethyl 3,3,3-trifluoro-2-diazopropionate 1 with ethyl cyanoformate.Starting from this acid, a number of i

Full text of DOI:10.1016/S0022-1139(00)80131-1

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