Facile synthesis of (+)-Brefeldin A

Article abstract of DOI:10.1016/S0040-4039(00)79936-9

(+)-Brefeldin A (1) was synthesized by using (+)-4-cyanomethylcyclopent-2-en-1-one (2) as a key compound. 4-Hydroxy-2-enoate functionality was built by the reaction of the aldehyde (7) with (S)-ethyl p-chlorophenylsulfinylacetate.