Tetrahedron p. 3925 - 3934 (1991)
Update date:2022-08-04
Topics:
Tsunoda, Tetsuto
Sasaki, Osamu
Takeuchi, Osamu
Ito, Sho
An efficient and versatile method for the hydrolysis of N-monosubstituted carboxamides has been developed. The method consists of two steps: the conversion to acetoxypivalimides (≥90% yield) and their mild alkaline hydrolysis (70 90% yield). No epimerization at the α-position of the acyl group took place in the process. The amine part of the original amides can be recovered in good yield.
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