Regiodefined synthesis and conformational properties of adenyldiyl trimers with unsymmetrical 2'-5' and 3'-5' internucleotide linkages

Article abstract of DOI:10.1016/0040-4020(95)00590-5

Adenyldiyl trimers with different kinds of substituents on 2'-5' and 3'-5' phosphate linkages have been synthesized in a general, regiodefined manner. Examination of the 2D NMR spectra reveals that the trimers with adenyl(2'-5')adenosine linkage make a syn-anti as well as syn-syn base stack between the two adenyl bases and exist as a mixture of the two conformers.