Milbemycin synthesis: Synthesis of 6β-hydroxy-3,4-dihydromilbemycin E

DOI: 10.1016/S0040-4039(00)79699-7

Source and publish data:

Tetrahedron Letters p. 2269 - 2272 (1991)

Update date:2022-07-29

Topics:

Authors:

Karim, Sufia

Parmee, Emma R.

Thomas, Eric J.

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Article abstract of DOI:10.1016/S0040-4039(00)79699-7

The hydroxycyclohexanone (7) is readily available via a Robinson annelation, and is converted into the hydroxybutenolide (15) which is incorporated into a synthesis of 6β-hydroxy-3,4-dihydromilbemycin E (28).

Full text of DOI:10.1016/S0040-4039(00)79699-7

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Product name:6β-Hydroxy-3,4-dihydromilbemycin E

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