Labelled Representatives of a Possible Intermediate of Fosfomycin Biosythesis in Streptomyces fradiae: Preparation of (R,S)-(2-Hydroxypropyl)-, (R,S)-, (R)-, (S)-(2-Hydroxypropylpropyl- and (R,S)-(2-Hydroxypropyl)phosphonic acid

Article abstract of DOI:10.1007/BF00809660

Racemic methyl O-benzyllactate was reduced to the alcohol, transformed into the bromide and reacted with triethylphosphite to give the diethylphosphonate.Removal of protecting groups afforded a phosphonic acid which was purified as its cyclohexylammonium