Journal of Organic Chemistry p. 2927 - 2928 (1993)
Update date:2022-08-05
Topics:
Chen, Shu-Hui
Fairchild, Craig
Mamber, Stephen W.
Farina, Vittorio
10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group.Compound 2 was found to possess comparable antitumor activity with respect to taxol.This confirms that the functional group at C-10 in taxol is not involved in receptor binding.
View MoreDayang Chem (Hangzhou) Co.,Ltd.
website:http://www.dycnchem.com
Contact:+86-571-88938639
Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
Basilea Pharmaceutica China Ltd.
Contact:+86-513-82198075
Address:No.638 Xiushan Road(East),Haimen, Jiangsu 226100, P.R.China
Contact:86-25-84683399
Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Reliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
SHANGHAI SYSTEAM BIOCHEM CO., LTD
website:http://www.systeambc.com
Contact:86-021-58380978
Address:Building 87，Lane 669， Dong Jing Road Shanghai,P.R.China
Doi:10.1002/anie.201106706
(2012)Doi:10.1021/ja511639b
(2015)Doi:10.1039/c2cc17124d
(2012)Doi:10.1134/S1070428015120027
(2015)Doi:10.1016/j.jorganchem.2011.12.018
(2012)Doi:10.1016/j.tetlet.2008.05.027
(2008)
