Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 10-Deoxytaxol

Article abstract of DOI:10.1021/jo00063a001

10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group.Compound 2 was found to possess comparable antitumor activity with respect to taxol.This confirms that the functional group at C-10 in taxol is not involved in receptor binding.