Journal of Organic Chemistry p. 2927 - 2928 (1993)
Update date:2022-08-05
Topics:
Chen, Shu-Hui
Fairchild, Craig
Mamber, Stephen W.
Farina, Vittorio
10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group.Compound 2 was found to possess comparable antitumor activity with respect to taxol.This confirms that the functional group at C-10 in taxol is not involved in receptor binding.
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