The synthesis and antifungal activity of 2-amino-4-aryl-4H,5H-benzothiopyranopyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-benzothiopyranopyridine-3-carbonitriles

Article abstract of DOI:10.1016/0223-5234(91)90033-J

This paper describes the synthesis of a series of 2-amino-4-aryl-4H,5H-<1>benzothiopyrano<4,3-b>pyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitriles.All of these products were studied for antifungal activity and many of these compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata, and Trichosporon cutaneum.