Electrochemical cleavage of sulfonamides: An efficient and tunable strategy to prevent β-fragmentation and epimerization

Article abstract of DOI:10.1021/ol300003f

The electrochemical reduction of sensitive sulfonamides is described. The addition of a benzoyl group on the nitrogen atom facilitates the reductive cleavage of sulfonamides preventing β-fragmentation and epimerization. This strategy was successfully applied to the cyclopropylamine and to α-amino stannanes.