Stereoselective synthesis of α-amino and α-thio β-lactones by conjugate addition of amine and thiol nucleophiles to α-methylene β-lactones and their decarboxylation to allylamines and sulfides

Article abstract of DOI:10.1021/jo00108a019

The stereoselective, conjugate addition of secondary, cyclic amines (pyrrolidine and piperidine) and mercaptans (thiophenol, isopropyl, and benzyl thiols and β-mercaptoethanol) to α-methylene β-lactones 1 and 2 was investigated. The corresponding α-(amino