Synthesis of 2,5-Dihydro-1,2,4-oxadiazoles through Formal [3+2] Cycloaddition of Oxazoles with Nitrosobenzene Derivatives

Article abstract of DOI:10.1246/bcsj.71.1231

The reactions of substituted oxazoles with nitrosobenzene gave 2-phenyl-2,5-dihydro-1,2,4-oxadiazoles regioselectively through formal [3+2] cycloadditions proceeding via a ringopening of oxazoles by an attack of nitrosobenzene. The reactions with 1-chloro