The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy

Article abstract of DOI:10.1016/0040-4020(95)00766-2

The preparation of novel monomethoxytrityl (Mmt) protected monomers for the synthesis of polyamide nucleic acids (PNAs) is described. The use of base-labile acyl-type nucleobase protecting groups and of a succinyl-linked solid-support offers a synthetic strategy to standard oligonucleotide synthesis conditions. This strategy has been successfully applied for the synthesis of PNAs of mixed base sequence.