Syntheses and Biological Characterization of Phosphorothioate Analogues of (3'-5')Adenylate Trimer

DOI: 10.1002/hlca.19910740420

Source and publish data:

Helvetica Chimica Acta p. 892 - 898 (1991)

Update date:2022-08-02

Topics:

Authors:

Charubala, Ramamurthy

Sobol, Robert W.

Kon, Ning

Suhadolnik, Robert J.

Pfleiderer, Wolfganag

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Article abstract of DOI:10.1002/hlca.19910740420

The four protected diastereoisomers 7a/7b and 8a/8b of P-thioadenylyl-(3'-5')-P-thioadenylyl-(3'-5')-adenosine were synthesized, separated, and deblocked to the free oligonucleotides (Scheme).Biochemical characterization of these (3'-5')phosphorothioate a

Full text of DOI:10.1002/hlca.19910740420

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