Nucleophilic substitution of 3-fluorosulfonyloxy cephalosporins with organocuprates

Article abstract of DOI:10.1016/S0040-4039(00)79294-X

3-Fluorosulfonyloxy cephems readily undergo addition-elimination reactions with organocuprates derived from the corresponding Grignard reagents. This chemistry presents an efficient, cost effective process for the preparation of 3-substituted cephems.