Nucleophilic substitution of 3-fluorosulfonyloxy cephalosporins with organocuprates

DOI: 10.1016/S0040-4039(00)79294-X

Source and publish data:

Tetrahedron Letters p. 7229 - 7230 (1993)

Update date:2022-08-03

Topics:

Authors:

Roth, Gregory P.

Peterson, Scott A.

Kant, Joydeep

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Article abstract of DOI:10.1016/S0040-4039(00)79294-X

3-Fluorosulfonyloxy cephems readily undergo addition-elimination reactions with organocuprates derived from the corresponding Grignard reagents. This chemistry presents an efficient, cost effective process for the preparation of 3-substituted cephems.

Full text of DOI:10.1016/S0040-4039(00)79294-X

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